Ruxolitinib, JAK inhibitor (TBI4511)
$126.00 – $270.00
Ruxolitinib, JAK inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4511-5MG | Yes | 5 MG | $126.00 | |||
TBI4511-25MG | Yes | 25 MG | $270.00 |
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Description
Product Details
Formal Name: βR-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile
Alternate Names: INCB 018424
Molecular Formula: C17H18N6
Formula Weight: 306.37
CAS Number: 941678-49-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 28 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
Storage: -20°C
Stability: ≥ 1 year.
Applications
JAK inhibitor
Functions
Potent and selective JAK1&2 inhibitor, IC50s=2.7, 4.5 and 322 nM forJAK1, JAK2 and JAK3 respectively. Blocks IL-6 signaling (IC50=281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50=127 nM). Inhibits the proinflammatory secretome of senescent cells. The JAK1 S646P mutant is highly sensitive to ruxolitinib. Clinically useful cancer chemotherapeutic.
Application Procedures
First dissolved in DMSO (up to 28 mg/ml) or in Ethanol (up to 15 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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