TASIN-1, Induces apoptosis in cells with APC truncations (TBI4890)
$126.00 – $495.00
Induces apoptosis in cells with APC truncations
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4890-5MG | Yes | 5 MG | $126.00 | |||
TBI4890-25MG | Yes | 25 MG | $495.00 |
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Description
Product Details
Formal Name: 1-[1-(4-Methoxyphenyl)sulfonylpiperidin-4-yl]-4-methylpiperidine hydrochloride
Molecular Formula: C18H28N2O3S·HCl
Formula Weight: 389.00
CAS Number: 1678515-13-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Induces apoptosis in cells with APC truncations
Functions
Selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene. IC50 = 70nM for DLD1 cell line. It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC;Apc) of colorectal cancer. TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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