Tryptanthrin, Immunomodulator; IDO2 inhibitor (TBI2228)
$99.00 – $360.00
Immunomodulator; IDO2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2228-5MG | Yes | 5 MG | $99.00 | |||
TBI2228-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: Indolo(2,1-b)quinazoline-6,12-dione
Alternate Names: NSC 349447; Couroupitine A
Molecular Formula: C15H8N2O2
Formula Weight: 248.24
CAS Number: 13220-57-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Immunomodulator; IDO2 inhibitor
Functions
A indoloquinazoline alkaloid found in various plant species and possessing intriguing pharmacological activities.1 Suppresses activation of BV2 microglia cells following LPS treatment and reduces production of proinflammatory cytokines via Nrf2, HO-1 and NFκB signaling. Displays antiinflammatory activity targeting IL-17. Inhibits indoleamine 2,3-dioxygenase 2 (IDO2) with an IC50 of 5-17 μM. Induces growth inhibition and neuronal differentiation in human neuroblastoma LA-N-1 cells.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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