HIF-2a-I2, HIF-2 antagonist (TBI1508)
$126.00 – $504.00
HIF-2 antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1508-5MG | Yes | 5 MG | $126.00 | |||
TBI1508-25MG | Yes | 25 MG | $504.00 |
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Description
Product Details
Formal Name: N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
Alternate Names: TC-S 7009
Molecular Formula: C12H6ClFN4O3
Formula Weight: 308.65
CAS Number: 1422955-31-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 35 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
HIF-2 antagonist
Functions
Potent and selective HIF-2α inhibitor, Kd=81 nM. Binds to the HIF-2α PAS-B domain and interferes with Hif-2α / ARNT heterodimerization reducing target gene expression in a cellular model. Highly selective for HIF-2α displaying a >60-fold selectivity over HIF-1α.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or in DMF (up to 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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