Gilteritinib, FLT3 inhibitor (TBI4170)
$126.00 – $450.00
FLT3 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4170-5MG | Yes | 5 MG | $126.00 | |||
TBI4170-25MG | Yes | 25 MG | $450.00 |
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Description
Product Details
Formal Name: 6-Ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide
Alternate Names: ASP2215
Molecular Formula: C29H44N8O3
Formula Weight: 552.70
CAS Number: 1254053-43-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
FLT3 inhibitor
Functions
Gilteritinib is a potent inhibitor of FLT3 (IC50 = 5 nM, wild-type FLT3) with more potent activity against all FLT3 mutants. It also potently inhibits Axl (IC50 = 41 nM). Clinically useful in the treatment of acute myeloid leukemia. Gilteritinib has also been shown to inhibit glutamine uptake and utilization via downregulation of glutamine transporters.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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