JNJ-63533054, GPR139 agonist, suppresses morphine intake (TBI3880)

Description

Product Details

Formal Name: (S)-3-Chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl) benzamide

Molecular Formula: C₁₇H₁₇ClN₂O₂

Formula Weight: 316.80

CAS Number: 1802326-66-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 35 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

 

Applications

GPR139 agonist, suppresses morphine intake

 

Functions

JNJ-63533054 is a potent and selective brain-penetrant GPR139 agonist (EC50=16 nM) an orphan G-protein-coupled receptor expressed in the CNS. Tritium-labeled JNJ-63533054 binds to cell membranes expressing GPR139 and can be displaced by putative endogenous ligands. Decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rodents. Suppresses morphine intake in a mouse self-administration model.

 

Application Procedures

First dissolved in DMSO (up to 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 2 months.

Additional information

SIZE (mg)	25 MG, 5 MG

TBI3880_Data_Sheet