BMS-309403, FABP4 inhibitor (TBI4762)
$108.00 – $405.00
FABP4 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4762-5MG | Yes | 5 MG | $108.00 | |||
TBI4762-25MG | Yes | 25 MG | $405.00 |
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Description
Product Details
Formal Name: 2-[3-[2-(5-Ethyl-3,4-diphenylpyrazol-1-yl)phenyl]phenoxy]acetic acid
Molecular Formula: C31H26N2O3
Formula Weight: 474.55
CAS Number: 300657-03-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
FABP4 inhibitor
Functions
BMS-309403 is a potent (Ki <2 nM FABP4, Ki = 250 nM FABP3, Ki = 350 nM FABP5) and selective inhibitor of the fatty-acid-binding protein aP2 (FABP4). It demonstrated marked reductions in atherosclerotic lesions in an Apoe-/- mouse model and improved glucose metabolism, reduced inflammation, and increased insulin sensitivity in a Lepob/ob mouse model. BMS-309403 stimulated glucose uptake in myotubes via activation of AMPK. It decreased ER stress-associated inflammation in skeletal muscle and suppressed inflammation and oxidative stress in mouse and cell models of acute lung injury.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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