UCPH-101, EAAT1 inhibitor (TBI4880)
$162.00 – $567.00
EAAT1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4880-5MG | Yes | 5 MG | $162.00 | |||
TBI4880-25MG | Yes | 25 MG | $567.00 |
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Description
Product Details
Formal Name: 2-Amino-4-(4-methoxyphenyl)-7-naphthalen-1-yl-5-oxo-4,6,7,8-tetrahydrochromene-3-carbonitrile
Molecular Formula: C27H22N2O3
Formula Weight: 422.48
CAS Number: 1118460-77-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
EAAT1 inhibitor
Functions
UCPH-101 is a potent (IC50 = 660 nM) and selective inhibitor of the excitatory amino acid transporter 1 (EAAT1). It induced cell death in glioblastoma cells via intracellular glutamate accumulation. UCPH-101 also significantly increased survival in glioma-bearing mice.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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