Phenylhexyl isothiocyanate, Chemopreventive; HDAC inhibitor; p53 reactivator (TBI5258)
$90.00 – $180.00
Chemopreventive; HDAC inhibitor; p53 reactivator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5258-5MG | Yes | 5 MG | $90.00 | |||
TBI5258-25MG | Yes | 25 MG | $180.00 |
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Description
Product Details
Formal Name: 6-isothiocyanatohexylbenzene
Alternate Names: PHITC; PHI
Molecular Formula: C13H17NS
Formula Weight: 219.40
CAS Number: 133920-06-6
Purity: >98%
Formulation: Liquid
Solubility: Soluble in DMSO (25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Chemopreventive; HDAC inhibitor; p53 reactivator
Functions
Isothiocyanate constituents of cruciferous vegetables are potent chemopreventive agents for carcinogen-induced cancers in rodents. PHITC was the most potent in a series of synthetic arylalkyl isothiocyantates at inhibition of tumorigenicity by NNK, a tobacco-derived nitrosamine, in a mouse model. It was also found to induce apoptosis and inhibit leukemia cell growth in vivo and was shown to have dual function as a histone deacetylase inhibitor and hypomethylating agent. PHITC was also shown to restore the activity of mutant p53 and reactivate the p53 pathway in human myeloid leukemia M2 cells.
Application Procedures
First dissolved in DMSO (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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