GW-2580, cFMS kinase inhibitor (TBI2143)
$130.00 – $518.00
cFMS kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2143-5MG | Yes | 5 MG | $130.00 | |||
TBI2143-25MG | Yes | 25 MG | $518.00 |
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Description
Product Details
Formal Name: 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
Molecular Formula: C20H22N4O3
Formula Weight: 366.32
CAS Number: 870483-87-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
cFMS kinase inhibitor
Functions
Potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases. Completely inhibits CSF-1 induced growth of mouse M-NFS-60 myeloid cells and human monocytes (at 1 μM). Completely inhibits bone degradation in human osteoclasts, rat calvaria and fetal long bone. Inhibits LPS-induced TNF production in mice. Abrogates infiltration of macrophages into synovial joints of arthritic mice. Active in vivo.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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