SU-9516, CDK inhibitor (pan-specific) (TBI5705)
$135.00 – $464.00
CDK inhibitor (pan-specific)
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI5705-5MG | Yes | 5 MG | $135.00 | |||
TBI5705-25MG | Yes | 25 MG | $464.00 |
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Description
Product Details
Formal Name: (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one
Molecular Formula: C13H11N3O2
Formula Weight: 241.30
CAS Number: 377090-84-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
CDK inhibitor (pan-specific)
Functions
A cyclin-dependent kinase inhibitor, IC50s= 0.02-0.03, 0.04-0.2, 0.2-1.7 and 0.9 µM for cdk2, cdk1, cdk4, cdk9 respectively. Inhibits phosphorylation of retinoblastoma protein pRb, causing enhanced pRb/E2f complex formation, cell cycle arrest at G1 and G2-M and apoptosis. Down-regulates antiapoptotic protein Mcl-1 expression resulting in mitochondrial injury and cell death. Inhibits epithelial-mesenchymal transition (IC50=1.21 µM) a crucial pathological event in tumor cell budding and metastasis. Cell permeable.
Application Procedures
First dissolved in DMSO (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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