Purvalanol A, CDK inhibitor (TBI2868)
$90.00 – $360.00
CDK inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2868-5MG | Yes | 5 MG | $90.00 | |||
TBI2868-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: (2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Alternate Names: NG-60
Molecular Formula: C19H25ClN6O
Formula Weight: 388.89
CAS Number: 212844-53-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 35 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
CDK inhibitor
Functions
Cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively. Reversibly arrests synchronized cells in G1 and G2 phase. Induces ER stress-mediated apoptosis and autophagy in colon cancer cells. Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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