MDL-28170 (Z-Val-Phe-CHO), Calpain inhibitor (TBI3005)
$86.00 – $360.00
Calpain inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3005-5MG | Yes | 5 MG | $86.00 | |||
TBI3005-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: N-Benzyloxycarbonylvalylphenylalaninal
Alternate Names: Z-Val-Phe-CHO; Calpain Inhibitor III
Molecular Formula: C22H26N2O4
Formula Weight: 382.40
CAS Number: 88191-84-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 75 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Calpain inhibitor
Functions
A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons. It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia. Displays neuroprotective effects in neurotrama rodent models. Calpain I Ki = 8 nM; Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 µM in intact cell assay.
Application Procedures
First dissolved in DMSO (up to 75 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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