KU-55933, ATM Kinase inhibitor (TBI1518)
$117.00 – $468.00
ATM Kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1518-5MG | Yes | 5 MG | $117.00 | |||
TBI1518-25MG | Yes | 25 MG | $468.00 |
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Description
Product Details
Formal Name: 2-(4-Morpholinyl)-6-(1-thiamthrenyl)-4H-pyran-4-one
Molecular Formula: C21H17NO3S2
Formula Weight: 395.50
CAS Number: 587871-26-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
ATM Kinase inhibitor
Functions
Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively. Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro. Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation. Sensitizes radio-resistant cancer cells. Provides neuroprotection against H2O2-induced cell damage.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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