VE-821, ATR inhibitor (TBI5589)
$144.00 – $522.00
ATR inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI5589-5MG | Yes | 5 MG | $144.00 | |||
TBI5589-25MG | Yes | 25 MG | $522.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide
Molecular Formula: C18H16N4O3S
Formula Weight: 368.40
CAS Number: 1232410-49-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (40 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
ATR inhibitor
Functions
A potent and selective ATP-competitive ATR (Ataxia-telangiectasia and Rad3-related protein) inhibitor, Ki=13 nM. Increases the sensitivity of pancreatic and ovarian cancer cells to radiation and chemotherapy. Increased replication stress induced by PARP inhibitors or chemotherapeutic agents increases sensitivity to VE-821 in neuroblastoma cells. Enhances the cytotoxicity of DNA damaging agents.
Application Procedures
First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “VE-821, ATR inhibitor (TBI5589)”
You must be logged in to post a review.
Reviews
There are no reviews yet.