ST-034307, Adenylate cyclase 1 inhibitor; Analgesic activity (TBI1620)
$117.00 – $450.00
Adenylate cyclase 1 inhibitor; Analgesic activity
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1620-5MG | Yes | 5 MG | $117.00 | |||
TBI1620-25MG | Yes | 25 MG | $450.00 |
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Description
Product Details
Formal Name: 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
Molecular Formula: C10H4Cl4O2
Formula Weight: 297.95
CAS Number: 133406-29-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)
Storage: RT
Stability: ≥ 1 year.
Applications
Adenylate cyclase 1 inhibitor; Analgesic activity
Functions
A novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC1. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation. Displays analgesic properties in a mouse model of inflammatory pain.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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