Stavudine, HIV reverse transcriptase inhibitor; NLRP3 inflammasome inhibitor (TBI1266)
$94.00 – $306.00
HIV reverse transcriptase inhibitor; NLRP3 inflammasome inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1266-200MG | Yes | 200mg | $94.00 | |||
TBI1266-1G | Yes | 1 G | $306.00 |
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Description
Product Details
Formal Name: 2′,3′-Didehydro-3′-deoxy-thymidine
Alternate Names: BMY 27857; d4T
Molecular Formula: C10H12N2O4
Formula Weight: 224.20
CAS Number: 3056-17-5
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml), or in Water (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
HIV reverse transcriptase inhibitor; NLRP3 inflammasome inhibitor
Functions
Thymidine derivative that acts as an HIV nucleoside reverse transcriptase inhibitor (NRTI) (EC50 = 8.8 nM for HIV-1 replication in human PBMCs). Down-modulates P2X7-mediated NLRP3 inflammasome activation independent of reverse transcriptase inhibition. Reduces production of IL-18 and caspase-1 and stimulates Aβ-induced autophagy in macrophages.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), or in Water (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or water may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 200mg, 1 G |
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