Mycalolide B, Actin depolymerizing agent (TBI2217)

Description

Product Details

Formal Name: From Mycale sp.

Molecular Formula: C₅₂H₇₄N₄O₁₇

Formula Weight: 1027.16

CAS Number: 122752-21-0

Purity: >98%

Formulation: Lyophilized

Solubility: Soluble in DMSO (up to 20 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

 

Applications

Actin depolymerizing agent

 

Functions

A novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM).1 It selectively and completely depolymerizes F-actin to G-actin via a novel mechanism different from that of the cytochalasin D.2 It is a novel and specific inhibitor of actomyosin ATPase.3

 

Application Procedures

First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Additional information

SIZE (mg)	20ug

TBI2217_Mycalolide B