Axitinib, VEGFR kinase inhibitor (TBI2118)

Description

Product Details

Formal Name: N-Methyl-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide

Molecular Formula: C₂₂H₁₈N₄OS

Formula Weight: 386.47

CAS Number: 319460-85-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

VEGFR kinase inhibitor

 

Functions

Potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular permeability. Also inhibits BCR-ABL1 (T315I) with high potency, Ki = 149 pM for autophosphorylated ABL1 (T315I). Inhibits proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Clinically useful anticancer agent.

 

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Additional information

SIZE (mg)	10 MG, 50 MG

TBI2118_Axitinib