ML-SA1, TRPML channel activator (TBI1439)
$135.00 – $540.00
TRPML channel activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1439-10MG | Yes | 10 MG | $135.00 | |||
TBI1439-50MG | Yes | 50 MG | $540.00 |
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Description
Product Details
Formal Name: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Molecular Formula: C22H22N2O3
Formula Weight: 362.43
CAS Number: 332382-54-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml with warming) or in Ethanol (up to 10 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
TRPML channel activator
Functions
TRPML 1,2 and 3 channel activator. Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 μM). Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages. Reduces intralysosomal Ca2+ level rescuing abnormal lysosomal storage in FIG4-deficient cells.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml with warming) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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