Halofuginone HBr, Prolyl-tRNA synthase inhibitor (TBI2381)
$72.00 – $118.00
Prolyl-tRNA synthase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2381-10MG | Yes | 10 MG | $72.00 | |||
TBI2381-50MG | Yes | 50 MG | $118.00 |
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Description
Product Details
Formal Name: (2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide
Alternate Names: NSC 713205
Molecular Formula: C16H17BrClN3O3 • HBr
Formula Weight: 495.60
CAS Number: 64924-67-0
Purity: >95%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Prolyl-tRNA synthase inhibitor
Functions
Potent and selective glutamyl-prolyl-tRNA synthetase inhibitor (Ki=18.3 nM) derived from the natural product febrifugine. Exhibits little toxicity at concentrations (<10 µM) that reduce TMPRSS2 protein levels via enhanced ubiquitination and proteasomal degradation. Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein and phosphorylation levels. Blocks fibrosis, angiogenesis, and tumor progression, as well as differentiation of TH17 immune cells. Simultaneously activates the Integrated Stress Response (ISR) and mTOR signaling in mouse embryo fibroblasts.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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