PIT-1, PH Domain antagonist (TBI1192)
$63.00 – $216.00
PH Domain antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1192-10MG | Yes | 10 MG | $63.00 | |||
TBI1192-50MG | Yes | 50 MG | $216.00 |
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Description
Product Details
Formal Name: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Molecular Formula: C14H10ClN3O4S
Formula Weight: 351.76
CAS Number: 53501-41-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
PH Domain antagonist
Functions
PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 μM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87mgglioblastoma cells (IC50 = 37 μM). Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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