Lomeguatrib, MGMT inhibitor (TBI4017)

Description

Product Details

Formal Name: 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine

Alternate Names: O6-(4-Bromothenyl)guanine

Molecular Formula: C₁₀H₈BrN₅O₃S

Formula Weight: 326.20

CAS Number: 192441-08-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml with warming)

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

MGMT inhibitor

 

Functions

Lomeguatrib is a potent (IC50 = 9 nM) inhibitor of O6-Methylguanine-DNA Methyltransferase (MGMT), an important DNA repair protein. It is currently being investigated in cancers that have acquired resistant to the chemotherapeutic temozolomide2-5, as well as other chemotherapeutics.

 

Application Procedures

First dissolved in DMSO (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

 

Additional information

SIZE (mg)	10 MG, 50 MG

TBI4017_Lomeguatrib