Tolcapone, COMT inhibitor; TTR aggregation inhibitor (TBI3075)
$90.00 – $360.00
COMT inhibitor; TTR aggregation inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3075-10MG | Yes | 10 MG | $90.00 | |||
TBI3075-50MG | Yes | 50 MG | $360.00 |
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Description
Product Details
Formal Name: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Molecular Formula: C14H11NO5
Formula Weight: 273.24
CAS Number: 134308-13-7
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
COMT inhibitor; TTR aggregation inhibitor
Functions
Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes. Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity. Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo. Inhibits O-methylation of exogenous polyphenols such as EGCG. Cell permeable. Orally bioavailable.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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