GF-109203X, PKC inhibitor (TBI1026)
$117.00 – $468.00
PKC inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1026-5MG | Yes | 5 MG | $117.00 | |||
TBI1026-25MG | Yes | 25 MG | $468.00 |
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Description
Product Details
Formal Name: 2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide
Alternate Names: Gö 6850; Bisindolylmaleimide I
Molecular Formula: C25H24N4O2
Formula Weight: 412.49
CAS Number: 133052-90-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
PKC inhibitor
Functions
Potent and selective protein kinase C inhibitor (IC50 = 10 nM; cAMP-dependent protein kinase IC50 = 2 µM and phosphorylase kinase IC50 = 0.7 µM). Inactive against the tyrosine kinases EGFR, PGDFR and Insulin receptor. Potent inhibitor of GSK-3β in cell lysates (IC50 = 360nM) and GSK-3β immunoprecipitates (IC50 = 170nM) derived from rat epididymal adipocytes. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 6 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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